Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure and function of extracellular loop 4 of the serotonin transporter as revealed by cysteine-scanning mutagenesis.

The Journal of biological chemistry - 4 Jun 2004

Mitchell Susan M, Lee Emily, Garcia Mayra L, Stephan Megan M

Abstract excerpt

Residues 386-423 of the rat brain serotonin transporter (SERT) are predicted to form a hydrophilic loop connecting transmembrane spans 7 and 8 (extracellular loop 4 or EL4). EL4 has been hypothesized to play a role in conformational changes associated with substrate translocation. To more fully investigate EL4 structure and function, we performed cysteine-scanning mutagenesis and methanethiosulfonate (MTS)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotinylation
Share to Cocaine
Share to Indicators and Reagents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mesylates

Share to Serotonin

Share to Serotonin Plasma Membrane Transport Proteins

Source

Identifiers

PMID: 15140876
DOI: 10.1074/jbc.M311173200

Genes

CIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure and function of extracellular loop 4 of the serotonin transporter as revealed by cysteine-scanning mutagenesis.PMID 15140876Read ↗

Cysteine-scanning mutagenesis of the fifth external loop of serotonin transporter.Semantic proximity Read ↗

Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.Semantic proximity Read ↗

Mutational scanning of the human serotonin transporter reveals fast translocating serotonin transporter mutants.Semantic proximity Read ↗

The external gate of the human and Drosophila serotonin transporters requires a basic/acidic amino acid pair for 3,4-methylenedioxymethamphetamine (MDMA) translocation and the induction of substrate efflux.Semantic proximity Read ↗

Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine.Semantic proximity Read ↗

Helix XI contributes to the entrance of the serotonin transporter permeation pathway.Semantic proximity Read ↗

Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.Semantic proximity Read ↗

The role of tyrosine residues in the extracellular domain of the 5-hydroxytryptamine3 receptor.Semantic proximity Read ↗

The loop C region of the murine 5-HT3A receptor contributes to the differential actions of 5-hydroxytryptamine and m-chlorophenylbiguanide.Semantic proximity Read ↗

Analysis of transmembrane domain 2 of rat serotonin transporter by cysteine scanning mutagenesis.Semantic proximity Read ↗

Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding.Semantic proximity Read ↗

Transmembrane domain 8 of the {gamma}-aminobutyric acid transporter GAT-1 lines a cytoplasmic accessibility pathway into its binding pocket.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.