Article
Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk.
Cancer - 1 Jan 2010
Dupont William D, Breyer Joan P, Bradley Kevin M, Schuyler Peggy A, Plummer W Dale, Sanders Melinda E, Page David L, Smith Jeffrey R
Abstract excerpt
BACKGROUND: Protein phosphatase 2A (PP2A) is a major cellular phosphatase and plays key regulatory roles in growth, differentiation, and apoptosis. Women who are diagnosed with benign proliferative breast disease are at increased risk for the subsequent development of breast cancer. METHODS: The authors evaluated genetic variation of PP2A holoenzyme subunits for their potential contribution to breast cancer risk....
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