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Article

Functional importance of PP2A regulatory subunit loss in breast cancer.

Breast cancer research and treatment - 1 Nov 2017

Watt Lauren F, Panicker Nikita, Mannan Abdul, Copeland Ben, Kahl Richard G S, Dun Matthew D, Young Barbara, Roselli Severine, Verrills Nicole M

Abstract excerpt

PURPOSE: Protein phosphatase 2A (PP2A) is a family of serine/threonine phosphatases that regulate multiple cellular signalling pathways involved in proliferation, survival and apoptosis. PP2A inhibition occurs in many cancers and is considered a tumour suppressor. Deletion/downregulation of PP2A genes has been observed in breast tumours, but the functional role of PP2A subunit loss in breast cancer has not been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28744751
DOI: 10.1007/s10549-017-4403-5

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