Article
Genetic variation in CYP19A1 and risk of breast cancer and fibrocystic breast conditions among women in Shanghai, China.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2008
Chen Chu, Sakoda Lori C, Doherty Jennifer A, Loomis Melissa M, Fish Sherianne, Ray Roberta M, Lin Ming Gang, Fan Wenhong, Zhao Lue Ping, Gao Dao Li, Stalsberg Helge, Feng Ziding, Thomas David B
Abstract excerpt
CYP19A1 encodes for aromatase, which irreversibly converts androgens to estrogens; variation in this gene may affect individual susceptibility to breast cancer and other sex hormone-dependent outcomes. In a case-control study nested within a breast self-examination trial conducted in China, we examined whether CYP19A1 polymorphisms (rs1870049, rs1004982, rs28566535, rs936306, , , ,...
