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Article

Recent natural selection identifies a genetic variant in a regulatory subunit of protein phosphatase 2A that associates with altered cancer risk and survival.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2009

Grochola Lukasz F, Vazquez Alexei, Bond Elisabeth E, Würl Peter, Taubert Helge, Müller Thomas H, Levine Arnold J, Bond Gareth L

Abstract excerpt

PURPOSE: A regulated p53-dependent stress response is crucial in suppressing tumor formation and mediating the response to commonly used cancer therapeutics. However, little is known about the human, inherited genetics of this important signaling pathway. EXPERIMENTAL DESIGN: Studies of human genetic variants in the p53 tumor suppressor gene and MDM2 oncogene have shown that single nucleotide polymorphisms (SNP)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19773383
DOI: 10.1158/1078-0432.CCR-09-0797

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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