Article
Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms.
Oncogene - 24 Feb 2000
Calin G A, di Iasio M G, Caprini E, Vorechovsky I, Natali P G, Sozzi G, Croce C M, Barbanti-Brodano G, Russo G, Negrini M
Abstract excerpt
The phosphatase 2A (PP2A) is one of the major cellular serine-threonine phosphatases. It was recently shown that the gene encoding for the beta isoform of its subunit A, PPP2R1B, is altered in human lung and colorectal carcinomas, suggesting a role in human tumorigenesis. Here, we report the detection of mutations in breast, lung carcinomas and melanomas in the genes of both alpha (PPP2R1A) and beta isoforms....
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