Identification and functional analyses of polymorphism haplotypes of protein phosphatase 2A-Aα gene promoter.

doi:10.1016/j.mrfmmm.2011.08.004

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Article

Identification and functional analyses of polymorphism haplotypes of protein phosphatase 2A-Aα gene promoter.

Mutation research - 1 Nov 2011

Lin Yu-Chun, Chen Hui-Feng, Lin Li-Na, Luo Jie, Li Wen, Zhang Shu-Jiang, Li Xiao-Jie, Hu Yao-Ming, Chen Yu-Xi, Chen Wen, Lin Zhong-Ning

Abstract excerpt

The serine-threonine protein phosphatase 2A (PP2A) is a heterotrimeric enzyme family that plays an essential regulatory role in cell growth, differentiation, and apoptosis. Mutations in the genes encoding PP2A-Aα/β subunits are associated with tumorigenesis and other human diseases. To explore whether genetic variations in the promoter region of the PP2A-Aα gene (PPP2R1A) and their frequent haplotypes in the Han...

Topics

5' Flanking Region
Base Sequence
Gene Expression Regulation
Humans
Linkage Disequilibrium
Molecular Sequence Data
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Protein Binding
Protein Phosphatase 2

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PMID: 21889517
DOI: 10.1016/j.mrfmmm.2011.08.004

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