Article
A genetic variant in a PP2A regulatory subunit encoded by the PPP2R2B gene associates with altered breast cancer risk and recurrence.
International journal of cancer - 15 May 2011
Vazquez Alexei, Kulkarni Diptee, Grochola Lukasz F, Bond Gareth L, Barnard Nicola, Toppmeyer Deborah, Levine Arnold J, Hirshfield Kim M
Abstract excerpt
A recent candidate gene association study identified a single nucleotide polymorphism (SNP) in the PPP2R2B gene (rs319217, A/G) that manifests allelic differences in the cellular responses to treatment with chemotherapeutic agents (Vazquez et al., Nat Rev Drug Discov 2008;7:979-87). This gene encodes a regulatory subunit of protein phosphatase 2A (PP2A), one of the major Ser/Thr phosphatases implicated in the...
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