Article
Identification and functional analysis of variant haplotypes in the 5'-flanking region of protein phosphatase 2A-Bδ gene.
PloS one - 1 Jan 2012
Chen Hui-Feng, Lin Li-Na, Chen Yu-Xi, Wan Jian-Xin, Luo Jie, Zhang Chen-Zi, Li Xiao-Jie, Hu Yao-Ming, Mai Jian-Rong, Chen Wen, Lin Zhong-Ning, Lin Yu-Chun
Abstract excerpt
Serine-threonine protein phosphatase 2A (PP2A) is a trimeric holoenzyme that plays an integral role in the regulation of cell growth, differentiation, and apoptosis. The substrate specificity and (sub)cellular localization of the PP2A holoenzymes are highly regulated by interaction with a family of regulatory B subunits (PP2A-Bs). The regulatory subunit PP2A-B/PR55δ (PP2A-Bδ) is involving in the dephosphorylation...
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