Article
BRCA1 regulates acetylation and ubiquitination of estrogen receptor-alpha.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 2010
Ma Yongxian, Fan Saijun, Hu Changyan, Meng Qinghui, Fuqua Suzanne A, Pestell Richard G, Tomita York A, Rosen Eliot M
Abstract excerpt
Inherited mutations of the breast cancer susceptibility gene BRCA1 confer a high risk for breast cancer development. The (300)RXKK and (266)KXK motifs have been identified previously as sites for acetylation of the estrogen receptor-alpha (ER-alpha), and (302)K was also found to be a site for BRCA1-mediated mono-ubiquitination of ER-alpha in vitro. Here we show that ER-alpha proteins with single or double lysine...
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