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Article

Phosphorylation of estrogen receptor alpha blocks its acetylation and regulates estrogen sensitivity.

Cancer research - 15 Dec 2004

Cui Yukun, Zhang Mao, Pestell Richard, Curran Edward M, Welshons Wade V, Fuqua Suzanne A W

Abstract excerpt

Estrogen receptor (ER) alpha is mutated (lysine 303 to arginine, K303R) in approximately one third of premalignant breast hyperplasias, which renders breast cancer cells expressing the mutant receptor hypersensitive for proliferation in response to low doses of estrogen. It is known that ERalpha is posttranslationally modified by protein acetylation and phosphorylation by a number of secondary messenger signaling...

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Identifiers

PMID: 15604293
DOI: 10.1158/0008-5472.CAN-04-2126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphorylation of estrogen receptor alpha blocks its acetylation and regulates estrogen sensitivity.PMID 15604293Read ↗

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