Article
Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase.
Molecular cell - 9 May 2008
Subramanian Krithika, Jia Da, Kapoor-Vazirani Priya, Powell Doris R, Collins Robert E, Sharma Dipali, Peng Junmin, Cheng Xiaodong, Vertino Paula M
Abstract excerpt
Estrogen receptor alpha (ER) is a ligand-dependent transcription factor. Upon binding estrogen, ER recruits coactivator complexes with histone acetyltransferase or methyltransferase activities to activate downstream target genes. In addition to histones, coactivators can modify ER itself and other proteins in the transactivation complex. Here, we show that ER is directly methylated at lysine 302 (K302) by the...
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