Article
Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity.
Nucleic acids research - 28 Feb 2017
McClurg Urszula L, Cork David M W, Darby Steven, Ryan-Munden Claudia A, Nakjang Sirintra, Mendes Côrtes Leticia, Treumann Achim, Gaughan Luke, Robson Craig N
Abstract excerpt
The androgen receptor (AR) is the main driver of prostate cancer (PC) development and progression, and the primary therapeutic target in PC. To date, two functional ubiquitination sites have been identified on AR, both located in its C-terminal ligand binding domain (LBD). Recent reports highlight the emergence of AR splice variants lacking the LBD that can arise during disease progression and contribute to...
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