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Article

Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylation.

Proceedings of the National Academy of Sciences of the United States of America - 22 Oct 2013

Zhang Xi, Tanaka Kaori, Yan Jiusheng, Li Jing, Peng Danni, Jiang Yuanyuan, Yang Zhe, Barton Michelle C, Wen Hong, Shi Xiaobing

Abstract excerpt

Estrogen receptor alpha (ERα) is a ligand-activated transcription factor. Upon estrogen stimulation, ERα recruits a number of coregulators, including both coactivators and corepressors, to the estrogen response elements, modulating gene activation or repression. Most coregulator complexes contain histone-modifying enzymes to control ERα target gene expression in an epigenetic manner. In addition to histones,...

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Source

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Identifiers

PMID: 24101509
DOI: 10.1073/pnas.1307959110
PMCID: PMC3808627

Genes

SMYD2
SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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