Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells.

Molecular endocrinology (Baltimore, Md.) - 1 Jan 2006

Ma Yongxian, Katiyar Pragati, Jones Laundette P, Fan Saijun, Zhang Yiyu, Furth Priscilla A, Rosen Eliot M

Abstract excerpt

The progesterone receptor (PR) plays roles in normal mammary development and breast cancer formation, where it may exert both stimulatory and inhibitory actions. Previously, the breast cancer susceptibility gene product BRCA1 was found to interact with and inhibit the transcriptional activity of estrogen receptor-alpha. In this study, we found that exogenous wild-type BRCA1 inhibited the activity of the PR in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Glands, Animal

Share to Mammary Tumor Virus, Mouse

Share to p300-CBP Transcription Factors

Share to Progesterone

Share to Receptors, Progesterone

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 16109739
DOI: 10.1210/me.2004-0488
PMCID: PMC4031608

Genes

BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells.PMID 16109739Read ↗

BRCA1 counteracts progesterone action by ubiquitination leading to progesterone receptor degradation and epigenetic silencing of target promoters.Semantic proximity Read ↗

Promotion of BRCA1-associated triple-negative breast cancer by ovarian hormones.Semantic proximity Read ↗

Progesterone-Independent Effects of Human Progesterone Receptors (PRs) in Estrogen Receptor-Positive Breast Cancer: PR Isoform-Specific Gene Regulation and Tumor BiologySemantic proximity Read ↗

Emerging roles of BRCA1 in transcriptional regulation and DNA repair.Semantic proximity Read ↗

Roles of BRCA1 and its interacting proteins.Semantic proximity Read ↗

BRCA1 gene in breast cancer.Semantic proximity Read ↗

The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.Semantic proximity Read ↗

Progesterone action in breast, uterine, and ovarian cancersSemantic proximity Read ↗

Decreased BRCA1 confers tamoxifen resistance in breast cancer cells by altering estrogen receptor-coregulator interactions.Semantic proximity Read ↗

Differential Gene Regulation by the Two Progesterone Receptor Isoforms in Human Breast Cancer CellsSemantic proximity Read ↗

Role of direct interaction in BRCA1 inhibition of estrogen receptor activity.Semantic proximity Read ↗

Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.