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Article

Acetylation targets HSD17B4 for degradation via the CMA pathway in response to estrone.

Autophagy - 4 Mar 2017

Zhang Ye, Xu Ying-Ying, Yao Chuan-Bo, Li Jin-Tao, Zhao Xiang-Ning, Yang Hong-Bin, Zhang Min, Yin Miao, Chen Jing, Lei Qun-Ying

Abstract excerpt

Dysregulation of hormone metabolism is implicated in human breast cancer. 17β-hydroxysteroid dehydrogenase type 4 (HSD17B4) catalyzes the conversion of estradiol (E2) to estrone (E1), and is associated with the pathogenesis and development of various cancers. Here we show that E1 upregulates HSD17B4 acetylation at lysine 669 (K669) and thereby promotes HSD17B4 degradation via chaperone-mediated autophagy (CMA),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28296597
DOI: 10.1080/15548627.2016.1268302
PMCID: PMC5361611

Genes

CREBBP
SIRT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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