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Article

Estrogen receptor α K303R mutation reorganizes its binding to forkhead box protein A1 regions and induces chromatin opening.

Molecular biology reports - 1 Feb 2023

Nakadai Tomoyoshi, Yang Liying, Kumegawa Kohei, Maruyama Reo

Abstract excerpt

BACKGROUND: Estrogen receptor alpha (ERα) is a frequently mutated gene in breast cancer (BC). While many studies have investigated molecular dysregulation by hotspot mutations at Y537 and D538, which exhibit an estrogen-independent constitutively active phenotype, the functional abnormalities of other mutations remain obscure. The K303R mutation in primary invasive BC has been implicated with endocrine...

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Share to Cell Line, Tumor
Share to Chromatin
Share to Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Forkhead Transcription Factors

Share to Gene Expression Regulation, Neoplastic

Share to Hepatocyte Nuclear Factor 3-alpha

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Identifiers

PMID: 36436079
DOI: 10.1007/s11033-022-08089-3
PMCID: PMC9889408

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