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Article

Sumoylation of the estrogen receptor alpha hinge region regulates its transcriptional activity.

Molecular endocrinology (Baltimore, Md.) - 1 Nov 2005

Sentis Stephanie, Le Romancer Murielle, Bianchin Claire, Rostan Marie-Claude, Corbo Laura

Abstract excerpt

The steroid hormone 17beta-estradiol (estrogen) plays a significant role in the normal physiology of the mammary gland and breast cancer development primarily through binding to its receptor, the estrogen receptor alpha (ERalpha). ERalpha is a nuclear transcription factor undergoing different types of posttranslational modifications, i.e. phosphorylation, acetylation, and ubiquitination, which regulate its...

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Source

Identifiers

PMID: 15961505
DOI: 10.1210/me.2005-0042

Genes

PIAS3
PIAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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