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Article

NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex.

Neuron - 28 Mar 2002

Hanley Jonathan G, Khatri Latika, Hanson Phyllis I, Ziff Edward B

Abstract excerpt

AMPA receptor (AMPAR) trafficking is crucial for synaptic plasticity that may be important for learning and memory. NSF and PICK1 bind the AMPAR GluR2 subunit and are involved in trafficking of AMPARs. Here, we show that GluR2, PICK1, NSF, and alpha-/beta-SNAPs form a complex in the presence of A...

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Source

Identifiers

PMID: 11931741
DOI: 10.1016/s0896-6273(02)00638-4

Genes

NSF
PICK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11931741-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex.PMID 11931741Read ↗

Uncoupling the ATPase activity of the N-ethylmaleimide sensitive factor (NSF) from 20S complex disassembly.Semantic proximity Read ↗

PICK1 mediates transient synaptic expression of GluA2-lacking AMPA receptors during glycine-induced AMPA receptor trafficking.Semantic proximity Read ↗

NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin.Semantic proximity Read ↗

PICK1 mediates synaptic recruitment of AMPA receptors at neurexin-induced postsynaptic sites.Semantic proximity Read ↗

α2δ-1 switches the phenotype of synaptic AMPA receptors by physically disrupting heteromeric subunit assembly.Semantic proximity Read ↗

PICK1 links KIBRA and AMPA receptors in coiled-coil-driven supramolecular complexesSemantic proximity Read ↗

LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate.Semantic proximity Read ↗

PICK1 links AMPA receptor stimulation to Cdc42.Semantic proximity Read ↗

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