Article
All-trans retinoic acid inhibits the differentiation, maturation, and function of human monocyte-derived dendritic cells.
Leukemia research - 1 Apr 2010
Jin Chun-Ji, Hong Cheol Yi, Takei Masao, Chung Sang-Young, Park Jung-Sun, Pham Thanh-Nhan Nguyen, Choi Soo-Jin-Na, Nam Jong-Hee, Chung Ik-Joo, Kim Hyeoung-Joon, Lee Je-Jung
Abstract excerpt
All-trans retinoic acid (ATRA) affects on the function of antigen presenting cells with somewhat controversies. We investigated the effects of ATRA on differentiation, maturation and function of human monocyte-derived dendritic cells (DCs). Low dose (10(-14)M) or high dose (10(-6)M) of ATRA was added either when monocytes were differentiated into immature DCs (imDCs) or mature DCs (mDCs) were induced. Apoptotic...
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