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Article

Solution and crystal molecular dynamics simulation study of m4-cyanovirin-N mutants complexed with di-mannose.

Biophysical journal - 4 Nov 2009

Vorontsov Ivan I, Miyashita Osamu

Abstract excerpt

Cyanovirin-N (CVN) is a highly potent anti-HIV carbohydrate-binding agent that establishes its microbicide activity through interaction with mannose-rich glycoprotein gp120 on the virion surface. The m4-CVN and P51G-m4-CVN mutants represent simple models for studying the high-affinity binding site, B(M). A recently determined 1.35 A high-resolution structure of P51G-m4-CVN provided details on the di-mannose...

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Identifiers

PMID: 19883596
DOI: 10.1016/j.bpj.2009.08.011
PMCID: PMC2770623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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