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Article

Rational and computational design of stabilized variants of cyanovirin-N that retain affinity and specificity for glycan ligands.

Biochemistry - 13 Dec 2011

Patsalo Vadim, Raleigh Daniel P, Green David F

Abstract excerpt

Cyanovirin-N (CVN) is an 11 kDa pseudosymmetric cyanobacterial lectin that has been shown to inhibit infection by the human immunodeficiency virus by binding to high-mannose oligosaccharides on the surface of the viral envelope glycoprotein gp120. In this work, we describe rationally designed CVN variants that stabilize the protein fold while maintaining high affinity and selectivity for their glycan targets....

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Identifiers

PMID: 22032696
DOI: 10.1021/bi201411c
PMCID: PMC3234137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Rational and computational design of stabilized variants of cyanovirin-N that retain affinity and specificity for glycan ligands.PMID 22032696Read ↗

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