Article
Design and initial characterization of a circular permuted variant of the potent HIV-inactivating protein cyanovirin-N.
Proteins - 1 Feb 2002
Barrientos Laura G, Louis John M, Hung Jason, Smith Trent H, O'Keefe Barry R, Gardella Roberta S, Mori Toshiyuki, Boyd Michael R, Gronenborn Angela M
Abstract excerpt
A circular permuted variant of the potent human immunodeficiency virus (HIV)-inactivating protein cyanovirin-N (CV-N) was constructed. New N- and C-termini were introduced into an exposed helical loop, and the original termini were linked using residues of the original loop. Since the three-dimensional structure of wild-type cyanovirin-N is a pseudodimer, the mutant essentially exhibits a swap between the two...
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