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Article

Solution and crystal structures of a sugar binding site mutant of cyanovirin-N: no evidence of domain swapping.

Structure (London, England : 1993) - 6 Aug 2008

Matei Elena, Furey William, Gronenborn Angela M

Abstract excerpt

The cyanobacterial lectin Cyanovirin-N (CV-N) exhibits antiviral activity against HIV at a low nanomolar concentration by interacting with high-mannose oligosaccharides on the virus surface envelope glycoprotein gp120. Atomic structures of wild-type CV-N revealed a monomer in solution and a domain-swapped dimer in the crystal, with the monomer comprising two independent carbohydrate binding sites that...

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Identifiers

PMID: 18682220
DOI: 10.1016/j.str.2008.05.011
PMCID: PMC2637156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Solution and crystal structures of a sugar binding site mutant of cyanovirin-N: no evidence of domain swapping.PMID 18682220Read ↗

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