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Article

Cyanovirin-N: a sugar-binding antiviral protein with a new twist.

Cellular and molecular life sciences : CMLS - 1 Feb 2003

Botos I, Wlodawer A

Abstract excerpt

Cyanovirin-N (CV-N), an 11-kDa protein from the cyanobacterium Nostoc ellipsosporum, is a highly potent virucidal agent that has generated interest as a lead natural product for the prevention and chemotherapy of human immunodeficiency virus infection. The antiviral activity of CV-N is mediated through specific, high-affinity interactions with the viral surface envelope glycoproteins. A number of structures of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12678493
DOI: 10.1007/s000180300023
PMCID: PMC11138712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Cyanovirin-N: a sugar-binding antiviral protein with a new twist.PMID 12678493Read ↗

Solution and crystal structures of a sugar binding site mutant of cyanovirin-N: no evidence of domain swapping.Semantic proximity Read ↗

Domain-swapped structure of a mutant of cyanovirin-N.Semantic proximity Read ↗

Design and initial characterization of a circular permuted variant of the potent HIV-inactivating protein cyanovirin-N.Semantic proximity Read ↗

Potent inhibition of HIV-1 fusion by cyanovirin-N requires only a single high affinity carbohydrate binding site: characterization of low affinity carbohydrate binding site knockout mutants.Semantic proximity Read ↗

Rational and computational design of stabilized variants of cyanovirin-N that retain affinity and specificity for glycan ligands.Semantic proximity Read ↗

Cyanovirin-N binds to select SARS-CoV-2 spike oligosaccharides outside of the receptor binding domain and blocks infection by SARS-CoV-2Semantic proximity Read ↗

Optimizing expression of antiviral cyanovirin-N homology gene using response surface methodology and protein structure prediction.Semantic proximity Read ↗

Conformational gating of dimannose binding to the antiviral protein cyanovirin revealed from the crystal structure at 1.35 A resolution.Semantic proximity Read ↗

Mutational pathways, resistance profile, and side effects of cyanovirin relative to human immunodeficiency virus type 1 strains with N-glycan deletions in their gp120 envelopes.Semantic proximity Read ↗

Flipping the switch from monomeric to dimeric CV-N has little effect on antiviral activity.Semantic proximity Read ↗

Rapid validation of the overall structure of an internal domain-swapped mutant of the anti-HIV protein cyanovirin-N using residual dipolar couplings.Semantic proximity Read ↗

Solution and crystal molecular dynamics simulation study of m4-cyanovirin-N mutants complexed with di-mannose.Semantic proximity Read ↗

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