Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of Glu41 in the binding of dimannose to P51G-m4-CVN.

Biochemistry - 11 Mar 2014

Ramadugu Sai Kumar, Li Zhen, Kashyap Hemant K, Margulis Claudio J

Abstract excerpt

The carbohydrate binding protein, Cyanovirin-N, obtained from cyanobacteria, consists of high-affinity and low-affinity binding domains. To avoid the formation of a domain swapped structure in solution and also to better focus on the binding of carbohydrates at the high-affinity site, the Ghirlanda group (Biochemistry, 46, 2007, 9199-9207) engineered the P51G-m4-CVN mutant which does not dimerize nor binds at the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Binding Sites
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mannose

Share to Molecular Dynamics Simulation

Share to Mutation

Share to Protein Binding

Source

Identifiers

PMID: 24524298
DOI: 10.1021/bi4014159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of Glu41 in the binding of dimannose to P51G-m4-CVN.PMID 24524298Read ↗

Solution and crystal structures of a sugar binding site mutant of cyanovirin-N: no evidence of domain swapping.Semantic proximity Read ↗

Potent inhibition of HIV-1 fusion by cyanovirin-N requires only a single high affinity carbohydrate binding site: characterization of low affinity carbohydrate binding site knockout mutants.Semantic proximity Read ↗

Solution and crystal molecular dynamics simulation study of m4-cyanovirin-N mutants complexed with di-mannose.Semantic proximity Read ↗

Rational and computational design of stabilized variants of cyanovirin-N that retain affinity and specificity for glycan ligands.Semantic proximity Read ↗

Conformational gating of dimannose binding to the antiviral protein cyanovirin revealed from the crystal structure at 1.35 A resolution.Semantic proximity Read ↗

Domain-swapped structure of a mutant of cyanovirin-N.Semantic proximity Read ↗

Molecular basis for differential nucleotide binding of the nucleotide-binding domain of ABC-transporter CvaB.Semantic proximity Read ↗

Cyanovirin-N: a sugar-binding antiviral protein with a new twist.Semantic proximity Read ↗

Stacking interactions between carbohydrate and protein quantified by combination of theoretical and experimental methods.Semantic proximity Read ↗

Flipping the switch from monomeric to dimeric CV-N has little effect on antiviral activity.Semantic proximity Read ↗

Signals of LOV1: a computer simulation study on the wildtype LOV1-domain of Chlamydomonas reinhardtii and its mutants.Semantic proximity Read ↗

Importance of hydrophobic and polar residues in ligand binding in the family 15 carbohydrate-binding module from Cellvibrio japonicus Xyn10C.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.