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Article

Domain-swapped structure of a mutant of cyanovirin-N.

Biochemical and biophysical research communications - 31 May 2002

Botos Istvan, Mori Toshiyuki, Cartner Laura K, Boyd Michael R, Wlodawer Alexander

Abstract excerpt

Cyanovirin-N (CV-N) is a potent 11 kDa HIV-inactivating protein that binds with high affinity to the HIV surface envelope protein gp120. A double mutant P51S/S52P of CV-N was engineered by swapping two critical hinge-region residues Pro51 and Ser52. This mutant has biochemical and biophysical characteristics equivalent to the wild-type CV-N and its structure resembles that of wild-type CV-N. However, the mutant...

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Identifiers

PMID: 12054761
DOI: 10.1016/S0006-291X(02)00455-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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