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Article

Flipping the switch from monomeric to dimeric CV-N has little effect on antiviral activity.

Structure (London, England : 1993) - 1 Oct 2004

Barrientos Laura G, Lasala Fátima, Delgado Rafael, Sanchez Anthony, Gronenborn Angela M

Abstract excerpt

Cyanovirin-N can exist in solution in monomeric and domain-swapped dimeric forms, with HIV-antiviral activity being reported for both. Here we present results for CV-N variants that form stable solution dimers: the obligate dimer [DeltaQ50]CV-N and the preferential dimer [S52P]CV-N. These variants exhibit comparable DeltaG values (10.6 +/- 0.5 and 9.4 +/- 0.5 kcal.mol(-1), respectively), similar to that of...

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Identifiers

PMID: 15458629
DOI: 10.1016/j.str.2004.07.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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