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Article

Flexibility in HIV-1 assembly subunits: solution structure of the monomeric C-terminal domain of the capsid protein.

Biophysical journal - 15 Aug 2007

Alcaraz Luis A, del Alamo Marta, Barrera Francisco N, Mateu Mauricio G, Neira José L

Abstract excerpt

The protein CA forms the mature capsid of human immunodeficiency virus. Hexamerization of the N-terminal domain and dimerization of the C-terminal domain, CAC, occur during capsid assembly, and both domains constitute potential targets for anti-HIV inhibitors. CAC homodimerization occurs mainly through its second helix, and is abolished when its sole tryptophan is mutated to alanine. Previous thermodynamic data...

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Capsid Proteins
Dimerization
HIV-1
Hydrophobic and Hydrophilic Interactions
Protein Structure, Secondary

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PMID: 17526561
DOI: 10.1529/biophysj.106.101089
PMCID: PMC1929042

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