Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conformational gating of dimannose binding to the antiviral protein cyanovirin revealed from the crystal structure at 1.35 A resolution.

Protein science : a publication of the Protein Society - 1 May 2008

Fromme Raimund, Katiliene Zivile, Fromme Petra, Ghirlanda Giovanna

Abstract excerpt

Cyanovirin (CV-N) is a small lectin with potent HIV neutralization activity, which could be exploited for a mucosal defense against HIV infection. The wild-type (wt) protein binds with high affinity to mannose-rich oligosaccharides on the surface of gp120 through two quasi-symmetric sites, located in domains A and B. We recently reported on a mutant of CV-N that contained a single functional mannose-binding site,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-HIV Agents
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Binding Sites

Share to Carrier Proteins

Share to Crystallography, X-Ray

Share to Mannose

Share to Nuclear Magnetic Resonance, Biomolecular

Share to Protein Conformation

Source

Open in PubMed Open full text

Identifiers

PMID: 18436959
DOI: 10.1110/ps.083472808
PMCID: PMC2327273

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conformational gating of dimannose binding to the antiviral protein cyanovirin revealed from the crystal structure at 1.35 A resolution.PMID 18436959Read ↗

Solution and crystal structures of a sugar binding site mutant of cyanovirin-N: no evidence of domain swapping.Semantic proximity Read ↗

Solution and crystal molecular dynamics simulation study of m4-cyanovirin-N mutants complexed with di-mannose.Semantic proximity Read ↗

Potent inhibition of HIV-1 fusion by cyanovirin-N requires only a single high affinity carbohydrate binding site: characterization of low affinity carbohydrate binding site knockout mutants.Semantic proximity Read ↗

Rational and computational design of stabilized variants of cyanovirin-N that retain affinity and specificity for glycan ligands.Semantic proximity Read ↗

Cyanovirin-N: a sugar-binding antiviral protein with a new twist.Semantic proximity Read ↗

How and why plants and human N-glycans are different: Insight from molecular dynamics into the “glycoblocks” architecture of complex carbohydratesSemantic proximity Read ↗

Synthetic Glycomacromolecules of Defined Valency, Absolute Configuration, and Topology Distinguish between Human LectinsSemantic proximity Read ↗

Cryo-EM Reconstruction of Dengue Virus in Complex with the Carbohydrate Recognition Domain of DC-SIGNSemantic proximity Read ↗

Carbohydrate-binding agents cause deletions of highly conserved glycosylation sites in HIV GP120: a new therapeutic concept to hit the achilles heel of HIV.Semantic proximity Read ↗

Domain-swapped structure of a mutant of cyanovirin-N.Semantic proximity Read ↗

The role of Glu41 in the binding of dimannose to P51G-m4-CVN.Semantic proximity Read ↗

Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antiviralsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.