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Identification and Characterization of a Novel Deoxyhypusine Synthase in Leishmania donovani

31 Oct 2009

Abstract excerpt

Deoxyhypusine synthase, an NAD(+)-dependent enzyme, catalyzes the first step in the post-translational synthesis of an unusual amino acid, hypusine (N(epsilon)-(4-amino-2-hydroxybutyl)lysine), in the eukaryotic initiation factor 5A precursor protein. Two putative deoxyhypusine synthase (DHS) sequences have been identified in the Leishmania donovani genome, which are present on chromosomes 20: DHSL20 (DHS-like...

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PMID: 19880510
DOI: 10.1074/jbc.m109.048850

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