Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adenine Aminohydrolase from Leishmania donovani

12 Jan 2012

Abstract excerpt

Adenine aminohydrolase (AAH) is an enzyme that is not present in mammalian cells and is found exclusively in Leishmania among the protozoan parasites that infect humans. AAH plays a paramount role in purine metabolism in this genus by steering 6-aminopurines into 6-oxypurines. Leishmania donovani AAH is 38 and 23% identical to Saccharomyces cerevisiae AAH and human adenosine deaminase enzymes, respectively,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical and Molecular Research
Share to Research on Leishmaniasis Studies
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22238346
DOI: 10.1074/jbc.m111.307884

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adenine Aminohydrolase from Leishmania donovaniPMID 22238346Read ↗

A conditional mutant deficient in hypoxanthine-guanine phosphoribosyltransferase and xanthine phosphoribosyltransferase validates the purine salvage pathway of Leishmania donovani.Semantic proximity Read ↗

Amplification of adenine phosphoribosyltransferase suppresses the conditionally lethal growth and virulence phenotype of Leishmania donovani mutants lacking both hypoxanthine-guanine and xanthine phosphoribosyltransferases.Semantic proximity Read ↗

Adenylosuccinate synthetase and adenylosuccinate lyase deficiencies trigger growth and infectivity deficits in Leishmania donovani.Semantic proximity Read ↗

Genetic analysis of purine metabolism in Leishmania donovani.Semantic proximity Read ↗

Purine Salvage Pathways in the Apicomplexan Parasite Toxoplasma gondiiSemantic proximity Read ↗

Xanthine phosphoribosyltransferase from Leishmania donovani. Molecular cloning, biochemical characterization, and genetic analysis.Semantic proximity Read ↗

IMP dehydrogenase deficiency in Leishmania donovani causes a restrictive growth phenotype in promastigotes but is not essential for infection in mice.Semantic proximity Read ↗

GMP reductase and genetic uncoupling of adenylate and guanylate metabolism in Leishmania donovani parasites.Semantic proximity Read ↗

Subcellular localization of adenine and xanthine phosphoribosyltransferases in Leishmania donovani.Semantic proximity Read ↗

Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cellSemantic proximity Read ↗

Genetically Engineered Ascorbic acid-deficient Live Mutants of Leishmania donovani induce long lasting Protective Immunity against Visceral Leishmaniasis.Semantic proximity Read ↗

S-adenosylmethionine decarboxylase from Leishmania donovani. Molecular, genetic, and biochemical characterization of null mutants and overproducers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.