Article

Characterization of thiamine pyrophospho kinase of vitamin B1 biosynthetic pathway as a drug target in Lesishmania donovani

2022-06-13

Abstract excerpt

Vitamin B1 is an essential cofactor required by carbohydrate-metabolizing enzymes such as Transketolases. Humans obtain these vitamins from their diet, although certain bacteria, yeast, plants, and lower eukaryotes synthesize them de novo . Because of the specificity of this system, the enzymes involved are amenable to therapeutic manipulation. In the final step of Thiamin Pyrophosphate (TPP) biosynthetic pathway,...

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Literature Corpus work: 2cda0530-1b7c-5554-929c-ea4c1e5503c9
DOI: 10.21203/rs.3.rs-1730070/v1

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