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Article

Pyridoxal kinase: A vitamin B6 salvage pathway enzyme from Leishmania donovani.

International journal of biological macromolecules - 1 Nov 2018

Kumar Vinay, Sharma Mahesh, Rakesh Bhadoriya Ruchita, Malik Chandan Kumar, Neelagiri Soumya, Neerupudi Kishore Babu, Garg Prabha, Singh Sushma

Abstract excerpt

Pyridoxal kinase (PdxK, EC 2.7.1.35) is an important enzyme of vitamin B6 salvage pathway which is required for phosphorylation of B6 vitamers. In the present study, pyridoxal kinase (pdxK) gene from Leishmania donovani (LdPdxK) was cloned and a 33 kDa protein was expressed and kinetically characterized. Site-directed mutagenesis was performed to determine the functional significance of conserved GXGD motif....

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Identifiers

PMID: 30031075
DOI: 10.1016/j.ijbiomac.2018.07.095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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