Article
Spermidine synthase is required for virulence of Leishmania donovani.
Infection and immunity - 1 Jul 2011
Gilroy Caslin, Olenyik Tamara, Roberts Sigrid C, Ullman Buddy
Abstract excerpt
Genetic lesions in the polyamine biosynthetic pathway of Leishmania donovani, the causal agent of visceral leishmaniasis, are conditionally lethal mutations that render the insect vector form of the parasite auxotrophic for polyamines. Recently, we have demonstrated that a Δodc L. donovani null mutant lacking ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, was profoundly...
Topics
- Animals
- Cell Line
- Gene Knockout Techniques
- Leishmania donovani
- Leishmaniasis, Visceral
- Mice
- Mutation
- Polyamines
- Spermidine Synthase