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Histone H4 lysine 14 acetylation in Leishmania donovani is mediated by the MYST-family protein HAT4

21 Oct 2011

Abstract excerpt

Post-translational modifications (PTMs) of histones regulate almost all facets of DNA metabolism in eukaryotes, such as replication, repair, transcription and chromatin condensation. While histone PTMs have been exhaustively examined in yeast and higher eukaryotes, less is known of their functional consequences in trypanosomatids. Trypanosome histones are highly divergent from those of other eukaryotes, and...

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PMID: 22016570
DOI: 10.1099/mic.0.050211-0

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