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Article

Xanthine phosphoribosyltransferase from Leishmania donovani. Molecular cloning, biochemical characterization, and genetic analysis.

The Journal of biological chemistry - 26 Nov 1999

Jardim A, Bergeson S E, Shih S, Carter N, Lucas R W, Merlin G, Myler P J, Stuart K, Ullman B

Abstract excerpt

Xanthine phosphoribosyltransferase (XPRT) from Leishmania donovani is a unique enzyme that lacks a mammalian counterpart and is, therefore, a potential target for antiparasitic therapy. To investigate the enzyme at the molecular and biochemical level, a cDNA encoding the L. donovani XPRT was isolated by functional complementation of a purine auxotroph of Escherichia coli that also harbors deficiencies in the...

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PMID: 10567419
DOI: 10.1074/jbc.274.48.34403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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