Article
Isolation and molecular characterization of the shikimate dehydrogenase domain from the Toxoplasma gondii AROM complex.
Molecular and biochemical parasitology - 1 Jan 2000
Peek James, Castiglione Gianni, Shi Thomas, Christendat Dinesh
Abstract excerpt
The apicomplexan parasite Toxoplasma gondii, the etiologic agent of toxoplasmosis, is estimated to infect 10-80% of different human populations. T. gondii encodes a large pentafunctional polypeptide known as the AROM complex which catalyzes five reactions in the shikimate pathway, a metabolic pathway required for the biosynthesis of the aromatic amino acids and a promising target for anti-parasitic agents. Here,...
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