Article

Genetic analysis of pyrimidine biosynthetic enzymes in <i>Plasmodium falciparum</i>

2025-12-01

Abstract excerpt

<h4>ABSTRACT</h4> The malaria parasite Plasmodium falciparum depends entirely on de novo pyrimidine synthesis, as it is unable to salvage these essential nucleotides. This reliance makes the pyrimidine biosynthesis pathway a compelling target for antimalarial drugs, with several inhibitors targeting its rate-limiting enzyme, dihydroorotate dehydrogenase ( Pf DHODH), already in clinical development. In this stu...

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Literature Corpus work: b6bff039-e778-5819-ad67-b0474625fa11
DOI: 10.1101/2025.11.30.691290

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