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Article

Posttranslational hypusination of the eukaryotic translation initiation factor-5A regulates Fusarium graminearum virulence.

Scientific reports - 21 Apr 2016

Martinez-Rocha Ana Lilia, Woriedh Mayada, Chemnitz Jan, Willingmann Peter, Kröger Cathrin, Hadeler Birgit, Hauber Joachim, Schäfer Wilhelm

Abstract excerpt

Activation of eukaryotic translation initiation factor eIF5A requires a posttranslational modification, forming the unique amino acid hypusine. This activation is mediated by two enzymes, deoxyhypusine synthase, DHS, and deoxyhypusine hydroxylase, DOHH. The impact of this enzymatic complex on the life cycle of a fungal pathogen is unknown. Plant pathogenic ascomycetes possess a single copy of the eIF5A activated...

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Identifiers

PMID: 27098988
DOI: 10.1038/srep24698
PMCID: PMC4838825

Genes

DOHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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