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Article

Development of tolerance in D3 dopamine receptor signaling is accompanied by distinct changes in receptor conformation.

Biochemical pharmacology - 15 Mar 2010

Westrich Ligia, Gil-Mast Sara, Kortagere Sandhya, Kuzhikandathil Eldo V

Abstract excerpt

The D3 but not D2 dopamine receptors exhibit a tolerance property in which agonist-induced D3 receptor response progressively decreases upon repeated agonist stimulation. We have previously shown that the D3 receptor tolerance property is not mediated by receptor internalization, persistent agonist binding or a decrease in receptor binding affinity. In this paper, we test the hypothesis that alterations in D3...

Topics

Animals
Biotinylation
Cell Line
Computer Simulation
Dopamine
Humans
Mice
Models, Biological
Molecular Biology
Mutation
Patch-Clamp Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation

Receptors, Dopamine D3

Signal Transduction

Structure-Activity Relationship

Sulfhydryl Compounds

Source

Identifiers

PMID: 19879251
DOI: 10.1016/j.bcp.2009.10.016

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