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Article

Development of tolerance in D3 dopamine receptor signaling is accompanied by distinct changes in receptor conformation.

Biochemical pharmacology - 15 Mar 2010

Westrich Ligia, Gil-Mast Sara, Kortagere Sandhya, Kuzhikandathil Eldo V

Abstract excerpt

The D3 but not D2 dopamine receptors exhibit a tolerance property in which agonist-induced D3 receptor response progressively decreases upon repeated agonist stimulation. We have previously shown that the D3 receptor tolerance property is not mediated by receptor internalization, persistent agonist binding or a decrease in receptor binding affinity. In this paper, we test the hypothesis that alterations in D3...

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Source

Identifiers

PMID: 19879251
DOI: 10.1016/j.bcp.2009.10.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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