Article
Identification of transmembrane regions critical for ligand binding to the human D3 dopamine receptor using various D3/D1 transmembrane chimeras.
Molecular pharmacology - 1 Aug 1998
Alberts G L, Pregenzer J F, Im W B
Abstract excerpt
To investigate the roles of individual transmembrane segments (TM) of the human D3 dopamine receptor in its ligand-receptor interactions, we generated chimeric receptors in which its TMs were replaced, one at a time, partially or entirely, by the corresponding TM of the homologous human D1 recept...
Topics
- Amino Acid Sequence
- Cell Membrane
- Humans
- Ligands
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Receptors, Dopamine D1
- Receptors, Dopamine D2
- Receptors, Dopamine D3
- Recombinant Fusion Proteins