Article
Pronounced conformational changes following agonist activation of the M(3) muscarinic acetylcholine receptor.
The Journal of biological chemistry - 1 Jul 2005
Han Sung-Jun, Hamdan Fadi F, Kim Soo-Kyung, Jacobson Kenneth A, Brichta Lars, Bloodworth Lanh M, Li Jian H, Wess Jürgen
Abstract excerpt
The conformational changes that convert G protein-coupled receptors (GPCRs) activated by diffusible ligands from their resting into their active states are not well understood at present. To address this issue, we used the M(3) muscarinic acetylcholine receptor, a prototypical class A GPCR, as a model system, employing a recently developed disulfide cross-linking strategy that allows the formation of disulfide...
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