Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An interaction involving an arginine residue in the cytoplasmic domain of the 5-HT3A receptor contributes to receptor desensitization mechanism.

The Journal of biological chemistry - 4 Aug 2006

Hu Xiang-Qun, Sun Hui, Peoples Robert W, Hong Ren, Zhang Li

Abstract excerpt

A large cytoplasmic domain accounts for approximately one-third of the entire protein of one superfamily of ligand-gated membrane ion channels, which includes nicotinic acetylcholine (nACh), gamma-aminobutyric acid type A (GABA(A)), serotonin type 3 (5-HT3), and glycine receptors. Desensitization is one functional feature shared by these receptors. Because most molecular studies of receptor desensitization have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to Arginine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoplasm

Share to Electrophysiology

Share to Ion Channel Gating

Share to Receptors, Serotonin, 5-HT3

Share to Static Electricity

Share to Xenopus laevis

Source

Identifiers

PMID: 16754678
DOI: 10.1074/jbc.M600676200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An interaction involving an arginine residue in the cytoplasmic domain of the 5-HT3A receptor contributes to receptor desensitization mechanism.PMID 16754678Read ↗

Structural determinants of Ca2+ permeability and conduction in the human 5-hydroxytryptamine type 3A receptor.Semantic proximity Read ↗

Aromatic residues at position 55 of rat alpha7 nicotinic acetylcholine receptors are critical for maintaining rapid desensitization.Semantic proximity Read ↗

Role of negatively charged amino acids in beta 4 F-loop in activation and desensitization of alpha 3 beta 4 rat neuronal nicotinic receptors.Semantic proximity Read ↗

Mutation of a conserved Gln residue does not abolish desensitization of acid-sensing ion channel 1Semantic proximity Read ↗

Essential role of the C148-C227 disulphide bridge in the human 5-HT2A homodimeric receptor.Semantic proximity Read ↗

Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1.Semantic proximity Read ↗

A hydrophobic residue in position 15 of the rP2X3 receptor slows desensitization and reveals properties beneficial for pharmacological analysis and high-throughput screening.Semantic proximity Read ↗

Identification of negative residues in the P2X3 ATP receptor ectodomain as structural determinants for desensitization and the Ca2+-sensing modulatory sites.Semantic proximity Read ↗

Dynamic modification of a mutant cytoplasmic cysteine residue modulates the conductance of the human 5-HT3A receptor.Semantic proximity Read ↗

A single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism.Semantic proximity Read ↗

Rapid desensitization of the rat α7 nAChR is facilitated by the presence of a proline residue in the outer β-sheet.Semantic proximity Read ↗

Role of charged residues in coupling ligand binding and channel activation in the extracellular domain of the glycine receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.