Article
Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor.
The Journal of biological chemistry - 2 Jul 2004
Panicker Sandip, Cruz Hans, Arrabit Christine, Suen Ka Fai, Slesinger Paul A
Abstract excerpt
Ligand-gated ion channel receptors mediate the response of fast neurotransmitters by opening in less than a millisecond. Here, we investigated the activation mechanism of a serotonin-gated receptor (5-HT(3A)) by systematically introducing cysteine substitutions throughout the pore-lining M1-M2 loop and M2 transmembrane domain. We hypothesized that multiple cysteines in the narrowest region of the pore, which...
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