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Article

The tolerance property of human D3 dopamine receptor is determined by specific amino acid residues in the second cytoplasmic loop.

Biochimica et biophysica acta - 1 Dec 2007

Westrich Ligia, Kuzhikandathil Eldo V

Abstract excerpt

The D2 and D3 dopamine receptor subtypes are structurally homologous and couple to the same signal transduction pathways. Nevertheless, their evolutionary conservation suggests that the two subtypes might exhibit unique signaling characteristics. We previously determined that D3 but not D2S dopamine receptor exhibits a tolerance property in which the D3 receptor-activated G-protein coupled inward rectifier...

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PMID: 17662480
DOI: 10.1016/j.bbamcr.2007.06.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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