Article
Detection of a new cerebral malaria susceptibility locus, using CBA mice.
Immunogenetics - 1 Dec 2004
Ohno Tamio, Nishimura Masahiko
Abstract excerpt
Human cerebral malaria (CM) during acute Plasmodium falciparum infection is a serious neurological complication that leads to coma and death. P. berghei ANKA infection of CBA mice is a useful experimental model of CM. To identify host susceptibility loci, we performed chromosomal mapping in crossbred populations of both CM-susceptible CBA and CM-resistant DBA/2 mice. One significant region for a CM-susceptible...
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