Article
Activation of the S-phase checkpoint inhibits degradation of the F-box protein Dia2.
Molecular and cellular biology - 1 Jan 2010
Kile Andrew C, Koepp Deanna M
Abstract excerpt
A stable genome is critical to cell viability and proliferation. During DNA replication, the S-phase checkpoint pathway responds to replication stress. In budding yeast, the chromatin-bound F-box protein Dia2 is required to maintain genomic stability and may help replication complexes overcome sites of damaged DNA and natural fragile regions. SCF (Skp1/Cul1/F-box protein) complexes are modular ubiquitin ligases....
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