Article
Fission yeast Cid12 has dual functions in chromosome segregation and checkpoint control.
Molecular and cellular biology - 1 Jun 2006
Win Thein Z, Stevenson Abigail L, Wang Shao-Win
Abstract excerpt
Fission yeast Cid12 is a member of the Cid1 family of specialized poly(A) polymerases. Like cells lacking cid1, cid12Delta mutants were shown to have checkpoint defects when DNA replication was inhibited. Here, we show that Cid12 is also required for faithful chromosome segregation and that mutation of amino acid residues predicted to be essential for poly(A) polymerase activity resulted in loss of Cid12 function...
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