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Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

4 Feb 2016

Abstract excerpt

The coordinated activity of DNA replication factors is a highly dynamic process that involves ubiquitin-dependent regulation. In this context, the ubiquitin-directed ATPase CDC-48/p97 recently emerged as a key regulator of chromatin-associated degradation in several of the DNA metabolic pathways that assure genome integrity. However, the spatiotemporal control of distinct CDC-48/p97 substrates in the chromatin...

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PMID: 26842564
DOI: 10.1038/ncomms10612

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